1.
Southeast Asian J Trop Med Public Health
;
2006 Jul; 37(4): 607-12
Article
in English
| IMSEAR
| ID: sea-31224
ABSTRACT
Sixteen antimalarial alkoxylated and hydroxylated chalcones were tested for their ability to inhibit recombinant plasmepsin II in vitro. The best inhibitory compounds had either a chloro or dimethylamino group at the 4-position of phenyl ring A in the chalcone template. Combination of the chalcones with chloroquine showed additivity or mild antagonism of Plasmodium falciparum K1 growth in culture.